ISSN 2146-8133
 

Case Report Open Access


Pyoderma Gangrenosum: A Paraneoplastic Syndrome Associated with Occult Colorectal Malignancy? Report of A Case and Review of Literature

Khalid Ahmed, Sudarsanam Raman, Nimalan Pathma-Nathan.

Cited by (1)

Abstract
Introduction: Pyoderma gangrenosum (PG) is an uncommon sterile inflammatory neutrophilic dermatosis. Approximately 50% of PG patients have associated inflammatory bowel disease, rheumatic disorders or malignancies. Literature search reported only 2 cases of PG in association with colorectal cancer (CRC).
Case Report: A 74-year-old patient presented to the emergency department with central abdominal pain and vomiting for 24 hours. Recently, the patient was worked up for iron deficiency anemia and was due to have colonoscopy. She was also discovered to have multiple skin lesions on her left hand, which were ulcerated, erythematous, indurated, and thick with scaly plaque. Initially the differential diagnosis included: neutrophilic dermatosis, atypical mycoblastosis or mycosis. Skin biopsy revealed PG. The skin lesion did not respond to high-dose systemic steroids. Two months later during presentation to the emergency department with abdominal pain, abdominal and pelvic CT showed proximal sigmoid colon mass with nodular extension probably involving adjacent small bowel loops but no liver metastasis. Colonoscopy showed stenosing sigmoid mass, which was confirmed by biopsy to be adenocarcinoma. Laparotomy with resection of the sigmoid, upper part of the rectum, and a short segment of the involved small bowel was performed. Histology confirmed adenocarcinoma of the sigmoid (T4N0Mx). The skin lesions healed spontaneously following surgery.
Conclusion: Early treatment of CRC can enhance the outcome of patients with PG, which may point toward a related pathological process. Furthermore, PG may be an important predictor of CRC. We advise on detailed gastrointestinal tract GIT investigation for unresponsive PG.

Key words: Pyoderma gangrenosum, colorectal cancer, paraneoplastic syndrome


 
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1
 

How to Cite this Article
Pubmed Style

Ahmed K, Raman S, Pathma-Nathan N. Pyoderma Gangrenosum: A Paraneoplastic Syndrome Associated with Occult Colorectal Malignancy? Report of A Case and Review of Literature. Arch Clin Exp Surg. 2015; 4(4): 226-230. doi:10.5455/aces.20130819020843


Web Style

Ahmed K, Raman S, Pathma-Nathan N. Pyoderma Gangrenosum: A Paraneoplastic Syndrome Associated with Occult Colorectal Malignancy? Report of A Case and Review of Literature. http://www.acesjournal.org/?mno=39834 [Access: January 19, 2018]. doi:10.5455/aces.20130819020843


AMA (American Medical Association) Style

Ahmed K, Raman S, Pathma-Nathan N. Pyoderma Gangrenosum: A Paraneoplastic Syndrome Associated with Occult Colorectal Malignancy? Report of A Case and Review of Literature. Arch Clin Exp Surg. 2015; 4(4): 226-230. doi:10.5455/aces.20130819020843



Vancouver/ICMJE Style

Ahmed K, Raman S, Pathma-Nathan N. Pyoderma Gangrenosum: A Paraneoplastic Syndrome Associated with Occult Colorectal Malignancy? Report of A Case and Review of Literature. Arch Clin Exp Surg. (2015), [cited January 19, 2018]; 4(4): 226-230. doi:10.5455/aces.20130819020843



Harvard Style

Ahmed, K., Raman, S. & Pathma-Nathan, N. (2015) Pyoderma Gangrenosum: A Paraneoplastic Syndrome Associated with Occult Colorectal Malignancy? Report of A Case and Review of Literature. Arch Clin Exp Surg, 4 (4), 226-230. doi:10.5455/aces.20130819020843



Turabian Style

Ahmed, Khalid, Sudarsanam Raman, and Nimalan Pathma-Nathan. 2015. Pyoderma Gangrenosum: A Paraneoplastic Syndrome Associated with Occult Colorectal Malignancy? Report of A Case and Review of Literature. Archives of Clinical and Experimental Surgery (ACES), 4 (4), 226-230. doi:10.5455/aces.20130819020843



Chicago Style

Ahmed, Khalid, Sudarsanam Raman, and Nimalan Pathma-Nathan. "Pyoderma Gangrenosum: A Paraneoplastic Syndrome Associated with Occult Colorectal Malignancy? Report of A Case and Review of Literature." Archives of Clinical and Experimental Surgery (ACES) 4 (2015), 226-230. doi:10.5455/aces.20130819020843



MLA (The Modern Language Association) Style

Ahmed, Khalid, Sudarsanam Raman, and Nimalan Pathma-Nathan. "Pyoderma Gangrenosum: A Paraneoplastic Syndrome Associated with Occult Colorectal Malignancy? Report of A Case and Review of Literature." Archives of Clinical and Experimental Surgery (ACES) 4.4 (2015), 226-230. Print. doi:10.5455/aces.20130819020843



APA (American Psychological Association) Style

Ahmed, K., Raman, S. & Pathma-Nathan, N. (2015) Pyoderma Gangrenosum: A Paraneoplastic Syndrome Associated with Occult Colorectal Malignancy? Report of A Case and Review of Literature. Archives of Clinical and Experimental Surgery (ACES), 4 (4), 226-230. doi:10.5455/aces.20130819020843





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