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Are we able to predict the outcome of Ewing sarcoma? Looking for clinical prognostic factors by a multidisciplinary approach

Coral Sánchez Pérez, Lydia Mediavilla Santos, Esther Carbó Laso, Diana María Crego Vita, José Antonio Calvo Haro, Francisco Javier Vaquero Martín.

Abstract
Objective: Our main goal was to assess the outcome of patients with Ewing sarcoma (EWS) and identify prognostic factors.
Methods: A retrospective review of 65 patients diagnosed with EWS at our institution between 1991 and 2013.
Results: Patients had a median age of 19 years (0.3-76), and 63.1% were males. Median tumor size was 10 cm (2-30). Primary sites included the limbs (42.2%), pelvis (23.4%), and chest wall (9.4%). 22 patients (34.4%) had metastatic disease. Treatment: Surgical resection in 45 patients (76.3%) and external beam radiotherapy in 48 patients (75%). Chemotherapy regimens: VAIA/EVAIA in 15 patients (33%), VAC/IE in 15 patients (33%), and VIAE in 10 patients (22%). After a mean follow-up of 40.7 months (p25-75; 13.3- 86.16), 5-year actuarial overall survival (OS) and progression-free survival (PFS) were 67.34% and 49.2%, respectively. As determined by univariate analysis, OS was influenced by stage (p=0.0141) and chemotherapy (p= 0.036). Neither sex, age, LDH levels, primary tumor location, nor size, surgery, or radiation therapy were correlated to outcome. In the multivariate model, only stage remained significant (p

Key words: Ewing sarcoma family of tumors, sarcoma surgery, chemotherapy, Ewing diagnosis

 

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Pubmed Style

Pérez CS, Santos LM, Laso EC, Vita DMC, Haro JAC, Martín FJV. Are we able to predict the outcome of Ewing sarcoma? Looking for clinical prognostic factors by a multidisciplinary approach. doi:10.5455/aces.20161017105732


Web Style

Pérez CS, Santos LM, Laso EC, Vita DMC, Haro JAC, Martín FJV. Are we able to predict the outcome of Ewing sarcoma? Looking for clinical prognostic factors by a multidisciplinary approach. www.scopemed.org/?mno=239116 [Access: June 23, 2017]. doi:10.5455/aces.20161017105732


AMA (American Medical Association) Style

Pérez CS, Santos LM, Laso EC, Vita DMC, Haro JAC, Martín FJV. Are we able to predict the outcome of Ewing sarcoma? Looking for clinical prognostic factors by a multidisciplinary approach. doi:10.5455/aces.20161017105732


Vancouver/ICMJE Style

Pérez CS, Santos LM, Laso EC, Vita DMC, Haro JAC, Martín FJV. Are we able to predict the outcome of Ewing sarcoma? Looking for clinical prognostic factors by a multidisciplinary approach. doi:10.5455/aces.20161017105732


Harvard Style

Pérez, C. S., Santos, L. M., Laso, E. C., Vita, D. M. C., Haro, J. A. C. & Martín, F. J. V. (2017) Are we able to predict the outcome of Ewing sarcoma? Looking for clinical prognostic factors by a multidisciplinary approach. doi:10.5455/aces.20161017105732


Turabian Style

Pérez, Coral Sánchez, Lydia Mediavilla Santos, Esther Carbó Laso, Diana María Crego Vita, José Antonio Calvo Haro, and Francisco Javier Vaquero Martín. 2017. Are we able to predict the outcome of Ewing sarcoma? Looking for clinical prognostic factors by a multidisciplinary approach. doi:10.5455/aces.20161017105732


Chicago Style

Pérez, Coral Sánchez, Lydia Mediavilla Santos, Esther Carbó Laso, Diana María Crego Vita, José Antonio Calvo Haro, and Francisco Javier Vaquero Martín. “Are we able to predict the outcome of Ewing sarcoma? Looking for clinical prognostic factors by a multidisciplinary approach.” doi:10.5455/aces.20161017105732


MLA (The Modern Language Association) Style

Pérez, Coral Sánchez, Lydia Mediavilla Santos, Esther Carbó Laso, Diana María Crego Vita, José Antonio Calvo Haro, and Francisco Javier Vaquero Martín. “Are we able to predict the outcome of Ewing sarcoma? Looking for clinical prognostic factors by a multidisciplinary approach.” doi:10.5455/aces.20161017105732


APA (American Psychological Association) Style

Pérez, C. S., Santos, L. M., Laso, E. C., Vita, D. M. C., Haro, J. A. C. & Martín, F. J. V. (2017) Are we able to predict the outcome of Ewing sarcoma? Looking for clinical prognostic factors by a multidisciplinary approach. doi:10.5455/aces.20161017105732