ISSN 2146-8133
 

Original Research (Original Article) Open Access


Solid pseudopapillary tumor of the pancreas: A population-based comparison with pancreatic ductal adenocarcinoma

G. Paul Wright, Alan T. Davis, Tracy J. Koehler, Brent J. Goslin, Mathew H. Chung.

Abstract
Objective: Solid-pseudopapillary tumor of the pancreas (SPTP) is a rare neoplasm that has been investigated only in individual case series from individual institutions. Here, the goal was to perform a population-based analysis of these rare tumors.
Methods: A query of the Surveillance, Epidemiology, and End Results (SEER) database was made for patients with malignant SPTP and pancreatic ductal adenocarcinoma (PDAC) from 2001-2010. The primary outcome measure was five-year overall survival. Cox regression analyses were performed using age, race, gender, tumor location, stage of tumor, and histologic type.
Results: 107 patients with SPTP and 53,353 with PDAC were identified for study. Patients with SPTP were younger (p<0.001), more often female (p<0.001), and less commonly white (p<0.001) than those with PDAC. SPTPs were also more frequently located in the tail (p<0.001), of lesser stage (p<0.001), and more likely to undergo surgical treatment (p<0.001) than PDAC. The overall 5-year survival was 84.7% for SPTP and 2.8% for PDAC. For those patients who underwent surgical treatment, 5-year overall and cancer-specific survival was 92.7% and 95.9% for SPTP and 13.5% and 16.7% for PDAC, respectively.
Conclusion: SPTP is a rare pancreatic neoplasm found more commonly in young women in the tail of the pancreas and is associated with a significantly more favorable prognosis than PDAC.

Key words: Pseudopapillary, pancreatic cancer, pancreatic mass, SPTP


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by G. Paul Wright
Articles by Alan T. Davis
Articles by Tracy J. Koehler
Articles by Brent J. Goslin
Articles by Mathew H. Chung
on Google
on Google Scholar
Article Statistics
 Viewed: 518
Downloaded: 179
Cited: 0

REFERENCES
1. Camp ER, Tamm EP, Gomez HF, Wang H, Evans DB. Unusual Pancreatic Tumors. In: Yeo CJ, Dempsey DT, Klein AS, Pemberton JH, Peters JH (eds.) Shackelford's Surgery of the Alimentary Tract, 6th ed. Elsevier Saunders, Pennsylvania, 2006;1431-9.
2. Ye J, Ma M, Cheng D, Yuan F, Deng X, Zhan Q, et al. Solid-Pseudopapillary Tumor of the Pancreas: Clinical Features, Pathological Characteristics, and Origin. J Surg Onc 2012;106:728-35. https://doi.org/10.1002/jso.23195 [Pubmed]   
3. Butte JM, Brennan MF, Gonen M, Tang LH, D'Angelica MI, Fong Y, et al. Solid Pseudopapillary Tumors of the Pancreas. Clinical Features, Surgical Outcomes, and Long-Term Survival in 45 Consecutive Patients from a Single Center. J Gastrointest Surg 2011;15:350-7. https://doi.org/10.1007/s11605-010-1337-1 [Pubmed]   
4. Reddy S, Cameron JL, Scudiere J, Hruban RH, Fishman EK, Ahuja N, et al. Surgical Management of Solid-Pseudopapillary Neoplasms of the Pancreas (Franz or Hamoudi Tumors): A Large Single-Institutional Series. J Am Coll Surg 2009;208:950-9. https://doi.org/10.1016/j.jamcollsurg.2009.01.044 [Pubmed]    [PMC Free Fulltext]   
5. Mortenson MM, Katz MHG, Tamm EP, Bhutani MS, Wang H, Evans DB, et al. Current diagnosis and management of unusual pancreatic tumors. Am J Surg 2008;196:100-13. https://doi.org/10.1016/j.amjsurg.2008.02.005 [Pubmed]   
6. Tang LH, Aydin H, Brennan MF, Klimstra DS. Clinically aggressive solid pseudopapillary tumors of the pancreas: a report of two cases with components of undifferentiated carcinoma and a comparative clinicopathologic analysis of 34 conventional cases. Am J Surg Pathol 2005;29:512-9. https://doi.org/10.1097/01.pas.0000155159.28530.88 [Pubmed]   
7. National Cancer Institute. Overview of the SEER program. Available via: http://seer.cancer.gov/ about/overview.html (Accessed: March 24, 2014).
8. Lee SE, Jang JY, Hwang DW, Park KW, Kim SW. Clinical Features and Outcome of Solid Pseudopapillary Neoplasm: Differences Between Adults and Children. Arch Surg 2008;143:1218-21. https://doi.org/10.1001/archsurg.143.12.1218 [Pubmed]   
9. Lucas FL, Stukel TA, Morris AM, Siewers AE, Birkmeyer JD. Race and surgical mortality in the United States. Ann Surg 2006;243:281-6. https://doi.org/10.1097/01.sla.0000197560.92456.32 [Pubmed]    [PMC Free Fulltext]   
10. Chang DC, Zhang Y, Mukherjee D, Wolfgang CL, Schulick RD, Cameron JL, et al. Variations in referral patterns to high-volume centers for pancreatic cancer. J Am Coll Surg 2009;209:720-6. https://doi.org/10.1016/j.jamcollsurg.2009.09.011 [Pubmed]    [PMC Free Fulltext]   
11. Papavramidis T, Papavramidis S. Solid pseudopapillary tumors of the pancreas: Review of 718 patients reported in the English literature. J Am Coll Surg 2005;200:965-72. https://doi.org/10.1016/j.jamcollsurg.2005.02.011 [Pubmed]   
12. Bilimoria KY, Bentrem DJ, Ko CY, Stewart AK, Winchester DP, Talamonti MS. National failure to operate on early stage pancreatic cancer. Ann Surg 2007;246:173-80. https://doi.org/10.1097/SLA.0b013e3180691579 [Pubmed]    [PMC Free Fulltext]   
13. Howlader N, Noone AM, Krapcho M, Garshell J, Neyman N, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Cho H, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2010. http://seer.cancer.gov/ csr/1975_2010 (Accessed: March 24, 2014).

How to Cite this Article
Pubmed Style

Wright GP, Davis AT, Koehler TJ, Goslin BJ, Chung MH. Solid pseudopapillary tumor of the pancreas: A population-based comparison with pancreatic ductal adenocarcinoma. Arch Clin Exp Surg. 2016; 5(3): 148-153. doi:10.5455/aces.20151102085951


Web Style

Wright GP, Davis AT, Koehler TJ, Goslin BJ, Chung MH. Solid pseudopapillary tumor of the pancreas: A population-based comparison with pancreatic ductal adenocarcinoma. http://www.acesjournal.org/?mno=203519 [Access: January 19, 2018]. doi:10.5455/aces.20151102085951


AMA (American Medical Association) Style

Wright GP, Davis AT, Koehler TJ, Goslin BJ, Chung MH. Solid pseudopapillary tumor of the pancreas: A population-based comparison with pancreatic ductal adenocarcinoma. Arch Clin Exp Surg. 2016; 5(3): 148-153. doi:10.5455/aces.20151102085951



Vancouver/ICMJE Style

Wright GP, Davis AT, Koehler TJ, Goslin BJ, Chung MH. Solid pseudopapillary tumor of the pancreas: A population-based comparison with pancreatic ductal adenocarcinoma. Arch Clin Exp Surg. (2016), [cited January 19, 2018]; 5(3): 148-153. doi:10.5455/aces.20151102085951



Harvard Style

Wright, G. P., Davis, A. T., Koehler, T. J., Goslin, B. J. & Chung, M. H. (2016) Solid pseudopapillary tumor of the pancreas: A population-based comparison with pancreatic ductal adenocarcinoma. Arch Clin Exp Surg, 5 (3), 148-153. doi:10.5455/aces.20151102085951



Turabian Style

Wright, G. Paul, Alan T. Davis, Tracy J. Koehler, Brent J. Goslin, and Mathew H. Chung. 2016. Solid pseudopapillary tumor of the pancreas: A population-based comparison with pancreatic ductal adenocarcinoma. Archives of Clinical and Experimental Surgery (ACES), 5 (3), 148-153. doi:10.5455/aces.20151102085951



Chicago Style

Wright, G. Paul, Alan T. Davis, Tracy J. Koehler, Brent J. Goslin, and Mathew H. Chung. "Solid pseudopapillary tumor of the pancreas: A population-based comparison with pancreatic ductal adenocarcinoma." Archives of Clinical and Experimental Surgery (ACES) 5 (2016), 148-153. doi:10.5455/aces.20151102085951



MLA (The Modern Language Association) Style

Wright, G. Paul, Alan T. Davis, Tracy J. Koehler, Brent J. Goslin, and Mathew H. Chung. "Solid pseudopapillary tumor of the pancreas: A population-based comparison with pancreatic ductal adenocarcinoma." Archives of Clinical and Experimental Surgery (ACES) 5.3 (2016), 148-153. Print. doi:10.5455/aces.20151102085951



APA (American Psychological Association) Style

Wright, G. P., Davis, A. T., Koehler, T. J., Goslin, B. J. & Chung, M. H. (2016) Solid pseudopapillary tumor of the pancreas: A population-based comparison with pancreatic ductal adenocarcinoma. Archives of Clinical and Experimental Surgery (ACES), 5 (3), 148-153. doi:10.5455/aces.20151102085951





Most Viewed Articles
  • Hirudotherapy /Leech therapy: Applications and Indications in Surgery
    Swaid Abdullah, Latief M. Dar, Adil Rashid, Anita Tewari
    Arch Clin Exp Surg. 2012; 1(3): 172-180
    » Abstract & References » doi: 10.5455/aces.20120402072447

  • Role of Probiotics in Dental Caries and Periodontal Disease
    Amit Bhardwaj, Shalu V Bhardwaj
    Arch Clin Exp Surg. 2012; 1(1): 45-49
    » Abstract & References » doi: 10.5455/aces.20120212100645

  • Attenuated familial adenomatous polyposis presenting as an abdominal wall mass
    Marc Paul Jose Lopez, John Paul Senon Gonzalez, Manuel Francisco Tanada Roxas
    Arch Clin Exp Surg. 2017; 6(1): 53-55
    » Abstract » doi: 10.5455/aces.20150809085449

  • Role of Ultrasonography (“Honeycomb Sign”) in Early Detection of Dengue Hemorrhagic Fever
    Sudhir Sachar, Sunder Goyal, Saurabh Sachar
    Arch Clin Exp Surg. 2013; 2(1): 38-42
    » Abstract & References » doi: 10.5455/aces.20120828025157

  • Use of Polyethylene Fiber (Ribbond) in Pediatric Dentistry
    Eda Arat Maden, Ceyhan Altun
    Arch Clin Exp Surg. 2012; 1(2): 110-115
    » Abstract & References » doi: 10.5455/aces.20120416115640

  • Barium Enema in the Diagnosis of Hirschsprung’s Disease: A Comparison with Rectal Biopsy
    Mohammad Abbas, Arshad Rashid, Asim Rafiq Laharwal, Ajaz Ahmad Wani, Shabir Ahmad Dar, Manzoor Ahamad Chalkoo, Showkat Majeed Kakroo
    Arch Clin Exp Surg. 2013; 2(4): 224-228
    » Abstract & References » doi: 10.5455/aces.20120703031135

  • Long-Term Productive Cough Caused by Tracheal Bronchus
    Chih-Hao Chen, Shih-Yi Lee, Ho Chang, Tzu-Ti Hung
    Arch Clin Exp Surg. 2012; 1(2): 120-121
    » Abstract & References » doi: 10.5455/aces.20120311102403

  • A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects
    Huseyin Karagoz, Celalettin Sever, Yalcin Bayram, Cihan Sahin, Yalcin Kulahci, Ersin Ulkur
    Arch Clin Exp Surg. 2012; 1(4): 237-248
    » Abstract & References » doi: 10.5455/aces.20120218124923

  • Day–Care Surgery for Pilonidal Sinus Using Sinotomy Technique and Fibrin Glue Injection
    Selim Sozen, Vedat Ozturk, Koray Das, Hasan Erdem, Suleyman Cetinkunar, Ilhan Bali
    Arch Clin Exp Surg. 2012; 1(3): 138-141
    » Abstract & References » doi: 10.5455/aces.20120625121721

  • Scorpion sting in a pregnant woman: A case report
    Selim Bozkurt, Mehmet Okumus, Besime Utku, Deniz Cemgil Arikan, Ugur Lok, Fatma Betul Duygu
    Arch Clin Exp Surg. 2015; 4(2): 118-120
    » Abstract & References » doi: 10.5455/aces.20121229025033

  • Most Downloaded
  • Attenuated familial adenomatous polyposis presenting as an abdominal wall mass
    Marc Paul Jose Lopez, John Paul Senon Gonzalez, Manuel Francisco Tanada Roxas
    Arch Clin Exp Surg. 2017; 6(1): 53-55
    » Abstract » doi: 10.5455/aces.20150809085449

  • Role of Probiotics in Dental Caries and Periodontal Disease
    Amit Bhardwaj, Shalu V Bhardwaj
    Arch Clin Exp Surg. 2012; 1(1): 45-49
    » Abstract & References » doi: 10.5455/aces.20120212100645

  • Patient Selection in Plastic Surgery: Recognizing Body Dysmorphic Disorder
    Cihan Sahin, Onat Yilmaz, Yalcin Bayram, Huseyin Karagoz, Celalettin Sever, Yalcin Kulahci, Alpay Ates
    Arch Clin Exp Surg. 2013; 2(2): 109-115
    » Abstract & References » doi: 10.5455/aces.20120722123102

  • Hirudotherapy /Leech therapy: Applications and Indications in Surgery
    Swaid Abdullah, Latief M. Dar, Adil Rashid, Anita Tewari
    Arch Clin Exp Surg. 2012; 1(3): 172-180
    » Abstract & References » doi: 10.5455/aces.20120402072447

  • Use of Polyethylene Fiber (Ribbond) in Pediatric Dentistry
    Eda Arat Maden, Ceyhan Altun
    Arch Clin Exp Surg. 2012; 1(2): 110-115
    » Abstract & References » doi: 10.5455/aces.20120416115640

  • A Study of Methods Used to Reduce Surgical Site Infections
    Stuart R. Walker, Tara Anderson
    Arch Clin Exp Surg. 2012; 1(1): 27-33
    » Abstract & References » doi: 10.5455/aces.20120213053645

  • Slow-Release Drug Deliver System with Polylactic Acid Hydrogels in Prevention of Tracheal Wall Fibroplasia
    Jinrang Li, Lili Peng, Jianjun Sun, Hongguang Guo, Kun Guo, Zuogang Li, Yao Tang, Xu Sun, Shuangqing Zhang
    Arch Clin Exp Surg. 2012; 1(1): 1-7
    » Abstract & References » doi: 10.5455/aces.20120220105531

  • Post-Traumatic Pancreatic Pseudocyst: Report of Two Cases with Review of Literature
    Sunder Goyal, Sudhir Sachar, Ram Kumar Verma, Snigdha Goyal
    Arch Clin Exp Surg. 2013; 2(4): 251-258
    » Abstract & References » doi: 10.5455/aces.20120524103614

  • A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects
    Huseyin Karagoz, Celalettin Sever, Yalcin Bayram, Cihan Sahin, Yalcin Kulahci, Ersin Ulkur
    Arch Clin Exp Surg. 2012; 1(4): 237-248
    » Abstract & References » doi: 10.5455/aces.20120218124923

  • Role of Ultrasonography (“Honeycomb Sign”) in Early Detection of Dengue Hemorrhagic Fever
    Sudhir Sachar, Sunder Goyal, Saurabh Sachar
    Arch Clin Exp Surg. 2013; 2(1): 38-42
    » Abstract & References » doi: 10.5455/aces.20120828025157

  • Most Cited Articles
  • Hirudotherapy /Leech therapy: Applications and Indications in Surgery
    Swaid Abdullah, Latief M. Dar, Adil Rashid, Anita Tewari
    Arch Clin Exp Surg. 2012; 1(3): 172-180
    » Abstract & References » doi: 10.5455/aces.20120402072447
    Cited : 8 times [Click to see citing articles]

  • Experimental Craniofacial Composite Tissue Allotransplantation (CCTA) Models in Rats
    Yalcin Kulahci, Yalcin Bayram, Huseyin Karagoz, Celalettin Sever, Cihan Sahin
    Arch Clin Exp Surg. 2012; 1(3): 181-187
    » Abstract & References » doi: 10.5455/aces.20120514010906
    Cited : 7 times [Click to see citing articles]

  • Thoracodorsal Artery Perforator Flap: Basic Surgical Determinants
    Celalettin Sever, Yalcin Bayram, Cihan Sahin
    Arch Clin Exp Surg. 2012; 1(4): 270-271
    » Abstract & References » doi: 10.5455/aces.20120506072849
    Cited : 6 times [Click to see citing articles]

  • Pre-expanded Supraclavicular Flap for Post-burn Neck Contractures
    Celalettin Sever, Cihan Sahin
    Arch Clin Exp Surg. 2012; 1(1): 61-62
    » Abstract & References » doi: 10.5455/aces.20120205090034
    Cited : 4 times [Click to see citing articles]

  • What is the Most Appropriate Animal Model for Experimental Diabetic Neuropathy Studies ?
    Huseyin Karagoz, Mustafa Tansel Kendirli
    Arch Clin Exp Surg. 2012; 1(3): 199-200
    » Abstract & References » doi: 10.5455/aces.20120514012617
    Cited : 3 times [Click to see citing articles]

  • Anesthetic Burns – A Burn Injury Due to A Combination of Local Anaesthetic and Heat Pack
    Stuart Robert Walker
    Arch Clin Exp Surg. 2012; 1(2): 127-128
    » Abstract & References » doi: 10.5455/aces.20120206110836
    Cited : 3 times [Click to see citing articles]

  • Day–Care Surgery for Pilonidal Sinus Using Sinotomy Technique and Fibrin Glue Injection
    Selim Sozen, Vedat Ozturk, Koray Das, Hasan Erdem, Suleyman Cetinkunar, Ilhan Bali
    Arch Clin Exp Surg. 2012; 1(3): 138-141
    » Abstract & References » doi: 10.5455/aces.20120625121721
    Cited : 3 times [Click to see citing articles]

  • A Review of the Prevention and Treatment of Hypertrophic Scars: Part II. Experimental Studies
    Huseyin Karagoz, Yalcin Bayram, Celalettin Sever, Cihan Sahin, Yalcin Kulahci, Ersin Ulkur
    Arch Clin Exp Surg. 2013; 2(1): 49-58
    » Abstract & References » doi: 10.5455/aces.20120218125115
    Cited : 3 times [Click to see citing articles]

  • Students’ View of Evidence-Based Medicine: A Survey in Switzerland
    Reto Kaderli, Larissa Burghardt, Carina Hansali, Adrian Businger
    Arch Clin Exp Surg. 2012; 1(1): 34-40
    » Abstract & References » doi: 10.5455/aces.20120217124737
    Cited : 3 times [Click to see citing articles]

  • Surgical Safety Checklists in Operative Medicine in Switzerland
    Reto Kaderli, Ramona Cecini Hertig, Urban Laffer, Adrian P. Businger
    Arch Clin Exp Surg. 2012; 1(3): 158-167
    » Abstract & References » doi: 10.5455/aces.20120410120119
    Cited : 3 times [Click to see citing articles]