ISSN 2146-8133
 

Original Research (Original Article) Open Access


The diagnostic value of tumor markers and endoscopy in patients with gastric disorders

Ozgur Turk.

Abstract
Aim: An endoscopy is mainly used to obtain an early diagnosis confirming or excluding a gastrointestinal cancer, and also to investigate the presence of other gastrointestinal diseases. The most common used tumor markers, namely carbohydrate antigen (CA) 19-9, carcinoembryonic antigen (CEA) and alpha fetoprotein (AFP), are not sufficient for an accurate screening method. Evidence is accumulating that increased serum tumor marker levels can be an urgent indicator of endoscopy in dyspeptic patients.
Materials and Methods: We analyzed serum tumor marker levels of patients who were admitted to Sivrihisar State Hospital with gastrointestinal system symptoms. CA 19-9, CEA and AFP serum levels were examined in forty patients who underwent upper gastrointestinal endoscopy and forty healthy volunteers.
Results: There was no significant difference between serum AFP and CA 19-9 levels of patients group and the control group (P = 0.218 and P = 0.107, respectively). Serum CEA levels were found to be significantly increased in the patient group (P < 0.05). CEA levels of patients with gastritis were significantly higher than in patients with other diagnoses (P = 0.011).
Conclusions: Tumor markers cannot detect any kind of digestive system malignancy. Physicians must pay attention to premalignant lesions due to gastric cancer development. We must pay more attention to diagnose gastric malignancy in patients who have increased CEA and CA 19-9 levels.

Key words: Dyspepsia, endoscopy, tumor markers


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Ozgur Turk
on Google
on Google Scholar
Article Statistics
 Viewed: 1436
Downloaded: 420
Cited: 0

REFERENCES
1. Webb A, Scott-Mackie P, Cunningham D, Norman A, Andreyev J, O'Brien M, et al. The prognostic value of serum and immunohistochemical tumour markers in advanced gastric cancer. Eur J Cancer 1996;32A:63-8. [DOI via Crossref]   
2. Ballehaninna UK, Chamberlain RS. The clinical utility of serum CA 19-9 in the diagnosis, prognosis and management of pancreatic adenocarcinoma: An evidence based appraisal. J Gastrointest Oncol 2012;3:105-19. [Pubmed]    [PMC Free Fulltext]   
3. Muretto P, Graziano F, Staccioli MP, Barbanti I, Bartolucci A, Paolini G, et al. An endogastric capsule for measuring tumor markers in gastric juice: An evaluation of the safety and efficacy of a new diagnostic tool. Ann Oncol 2003;14:105-9. [DOI via Crossref]    [Pubmed]   
4. Polat E, Duman U, Duman M, Derya Peker K, Akyuz C, Fatih Yasar N, et al. Preoperative serum tumor marker levels in gastric cancer. Pak J Med Sci 2014;30:145-9. [Pubmed]    [PMC Free Fulltext]   
5. Gospodarowicz M, Mackillop W, O'Sullivan B, Sobin L, Henson D, Hutter RV, et al. Prognostic factors in clinical decision making: The future. Cancer 2001;91:1688-95. [DOI via Crossref]   
6. Turkyilmaz A, Eroglu A, Aydin Y, Karaoglanoglu N. The relationship of serum CEA and CA 19-9 levels to liver metastasis and pancreatic invasion in esophageal cancer. Turk J Med Sci 2009;39:895-9.
7. Perkins GL, Slater ED, Sanders GK, Prichard JG. Serum tumor markers. Am Fam Physician 2003;68:1075-82. [Pubmed]   
8. Takahashi Y, Takeuchi T, Sakamoto J, Touge T, Mai M, Ohkura H, et al. The usefulness of CEA and/ or CA19-9 in monitoring for recurrence in gastric cancer patients: A prospective clinical study. Gastric Cancer 2003;6:142-5. [DOI via Crossref]    [Pubmed]   
9. Janssen CW Jr, Orjasaeter H. Carcinoembryonic antigen in patients with gastric carcinoma. Eur J Surg Oncol 1986;12:19-23. [Pubmed]   
10. Koga T, Kano T, Souda K, Oka N, Inokuchi K. The clinical usefulness of preoperative CEA determination in gastric cancer. Jpn J Surg 1987;17:342-7. [DOI via Crossref]    [Pubmed]   
11. Kim YH, Ajani JA, Ota DM, Lynch P, Roth JA. Value of serial carcinoembryonic antigen levels in patients with resectable adenocarcinoma of the esophagus and stomach. Cancer 1995;75:451-6. [DOI via Crossref]   
12. Nishiyama M, Takashima I, Tanaka T, Yoshida K, Toge T, Nagata N, et al. Carcinoembryonic antigen levels in the peritoneal cavity: Useful guide to peritoneal recurrence and prognosis for gastric cancer. World J Surg 1995;19:133-77. 13.
13. Duraker N, Celik AN. The prognostic significance of preoperative serum CA 19-9 in patients with resectable gastric carcinoma: Comparison with CEA. J Surg Oncol 2001;76:266-71. [DOI via Crossref]    [Pubmed]   
14. Iwasaki Y, Arai K, Katayanagi S, Takahashi K, Yamaguchi T, Matsumoto H, et al. Biomarkers for neoplasmas in digestive organs. Gan To Kagaku Ryoho 2004;31:1015-20. [Pubmed]   
15. Micali B, Florio MG, Venuti A, Artemisia A, Caputo G, Brancato U. Usefulness of carcinoembryonic antigen measurement in gastric juice of patients with gastric disorders. J Clin Gastroenterol 1983;5:411-5. [DOI via Crossref]    [Pubmed]   
16. Farinati F, Nitti D, Cardin F, Di Mario F, Costa F, Rossi C, et al. CA 19-9 determination in gastric juice: Role in identifying gastric cancer and high risk patients. Eur J Cancer Clin Oncol 1988;24:923-7. [DOI via Crossref]   
17. de Vries AC, van Grieken NC, Looman CW, Casparie MK, de Vries E, Meijer GA, et al. Gastric cancer risk in patients with premalignant gastric lesions: A nationwide cohort study in the Netherlands. Gastroenterology 2008;134:945-52. [DOI via Crossref]    [Pubmed]   

How to Cite this Article
Pubmed Style

Ozgur Turk. The diagnostic value of tumor markers and endoscopy in patients with gastric disorders. Arch Clin Exp Surg. 2015; 4(2): 74-78. doi:10.5455/aces.20140531053930


Web Style

Ozgur Turk. The diagnostic value of tumor markers and endoscopy in patients with gastric disorders. http://www.acesjournal.org/?mno=159820 [Access: January 19, 2018]. doi:10.5455/aces.20140531053930


AMA (American Medical Association) Style

Ozgur Turk. The diagnostic value of tumor markers and endoscopy in patients with gastric disorders. Arch Clin Exp Surg. 2015; 4(2): 74-78. doi:10.5455/aces.20140531053930



Vancouver/ICMJE Style

Ozgur Turk. The diagnostic value of tumor markers and endoscopy in patients with gastric disorders. Arch Clin Exp Surg. (2015), [cited January 19, 2018]; 4(2): 74-78. doi:10.5455/aces.20140531053930



Harvard Style

Ozgur Turk (2015) The diagnostic value of tumor markers and endoscopy in patients with gastric disorders. Arch Clin Exp Surg, 4 (2), 74-78. doi:10.5455/aces.20140531053930



Turabian Style

Ozgur Turk. 2015. The diagnostic value of tumor markers and endoscopy in patients with gastric disorders. Archives of Clinical and Experimental Surgery (ACES), 4 (2), 74-78. doi:10.5455/aces.20140531053930



Chicago Style

Ozgur Turk. "The diagnostic value of tumor markers and endoscopy in patients with gastric disorders." Archives of Clinical and Experimental Surgery (ACES) 4 (2015), 74-78. doi:10.5455/aces.20140531053930



MLA (The Modern Language Association) Style

Ozgur Turk. "The diagnostic value of tumor markers and endoscopy in patients with gastric disorders." Archives of Clinical and Experimental Surgery (ACES) 4.2 (2015), 74-78. Print. doi:10.5455/aces.20140531053930



APA (American Psychological Association) Style

Ozgur Turk (2015) The diagnostic value of tumor markers and endoscopy in patients with gastric disorders. Archives of Clinical and Experimental Surgery (ACES), 4 (2), 74-78. doi:10.5455/aces.20140531053930





Most Viewed Articles
  • Hirudotherapy /Leech therapy: Applications and Indications in Surgery
    Swaid Abdullah, Latief M. Dar, Adil Rashid, Anita Tewari
    Arch Clin Exp Surg. 2012; 1(3): 172-180
    » Abstract & References » doi: 10.5455/aces.20120402072447

  • Role of Probiotics in Dental Caries and Periodontal Disease
    Amit Bhardwaj, Shalu V Bhardwaj
    Arch Clin Exp Surg. 2012; 1(1): 45-49
    » Abstract & References » doi: 10.5455/aces.20120212100645

  • Attenuated familial adenomatous polyposis presenting as an abdominal wall mass
    Marc Paul Jose Lopez, John Paul Senon Gonzalez, Manuel Francisco Tanada Roxas
    Arch Clin Exp Surg. 2017; 6(1): 53-55
    » Abstract » doi: 10.5455/aces.20150809085449

  • Role of Ultrasonography (“Honeycomb Sign”) in Early Detection of Dengue Hemorrhagic Fever
    Sudhir Sachar, Sunder Goyal, Saurabh Sachar
    Arch Clin Exp Surg. 2013; 2(1): 38-42
    » Abstract & References » doi: 10.5455/aces.20120828025157

  • Use of Polyethylene Fiber (Ribbond) in Pediatric Dentistry
    Eda Arat Maden, Ceyhan Altun
    Arch Clin Exp Surg. 2012; 1(2): 110-115
    » Abstract & References » doi: 10.5455/aces.20120416115640

  • Barium Enema in the Diagnosis of Hirschsprung’s Disease: A Comparison with Rectal Biopsy
    Mohammad Abbas, Arshad Rashid, Asim Rafiq Laharwal, Ajaz Ahmad Wani, Shabir Ahmad Dar, Manzoor Ahamad Chalkoo, Showkat Majeed Kakroo
    Arch Clin Exp Surg. 2013; 2(4): 224-228
    » Abstract & References » doi: 10.5455/aces.20120703031135

  • Long-Term Productive Cough Caused by Tracheal Bronchus
    Chih-Hao Chen, Shih-Yi Lee, Ho Chang, Tzu-Ti Hung
    Arch Clin Exp Surg. 2012; 1(2): 120-121
    » Abstract & References » doi: 10.5455/aces.20120311102403

  • A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects
    Huseyin Karagoz, Celalettin Sever, Yalcin Bayram, Cihan Sahin, Yalcin Kulahci, Ersin Ulkur
    Arch Clin Exp Surg. 2012; 1(4): 237-248
    » Abstract & References » doi: 10.5455/aces.20120218124923

  • Day–Care Surgery for Pilonidal Sinus Using Sinotomy Technique and Fibrin Glue Injection
    Selim Sozen, Vedat Ozturk, Koray Das, Hasan Erdem, Suleyman Cetinkunar, Ilhan Bali
    Arch Clin Exp Surg. 2012; 1(3): 138-141
    » Abstract & References » doi: 10.5455/aces.20120625121721

  • Scorpion sting in a pregnant woman: A case report
    Selim Bozkurt, Mehmet Okumus, Besime Utku, Deniz Cemgil Arikan, Ugur Lok, Fatma Betul Duygu
    Arch Clin Exp Surg. 2015; 4(2): 118-120
    » Abstract & References » doi: 10.5455/aces.20121229025033

  • Most Downloaded
  • Attenuated familial adenomatous polyposis presenting as an abdominal wall mass
    Marc Paul Jose Lopez, John Paul Senon Gonzalez, Manuel Francisco Tanada Roxas
    Arch Clin Exp Surg. 2017; 6(1): 53-55
    » Abstract » doi: 10.5455/aces.20150809085449

  • Role of Probiotics in Dental Caries and Periodontal Disease
    Amit Bhardwaj, Shalu V Bhardwaj
    Arch Clin Exp Surg. 2012; 1(1): 45-49
    » Abstract & References » doi: 10.5455/aces.20120212100645

  • Patient Selection in Plastic Surgery: Recognizing Body Dysmorphic Disorder
    Cihan Sahin, Onat Yilmaz, Yalcin Bayram, Huseyin Karagoz, Celalettin Sever, Yalcin Kulahci, Alpay Ates
    Arch Clin Exp Surg. 2013; 2(2): 109-115
    » Abstract & References » doi: 10.5455/aces.20120722123102

  • Hirudotherapy /Leech therapy: Applications and Indications in Surgery
    Swaid Abdullah, Latief M. Dar, Adil Rashid, Anita Tewari
    Arch Clin Exp Surg. 2012; 1(3): 172-180
    » Abstract & References » doi: 10.5455/aces.20120402072447

  • Use of Polyethylene Fiber (Ribbond) in Pediatric Dentistry
    Eda Arat Maden, Ceyhan Altun
    Arch Clin Exp Surg. 2012; 1(2): 110-115
    » Abstract & References » doi: 10.5455/aces.20120416115640

  • A Study of Methods Used to Reduce Surgical Site Infections
    Stuart R. Walker, Tara Anderson
    Arch Clin Exp Surg. 2012; 1(1): 27-33
    » Abstract & References » doi: 10.5455/aces.20120213053645

  • Slow-Release Drug Deliver System with Polylactic Acid Hydrogels in Prevention of Tracheal Wall Fibroplasia
    Jinrang Li, Lili Peng, Jianjun Sun, Hongguang Guo, Kun Guo, Zuogang Li, Yao Tang, Xu Sun, Shuangqing Zhang
    Arch Clin Exp Surg. 2012; 1(1): 1-7
    » Abstract & References » doi: 10.5455/aces.20120220105531

  • Post-Traumatic Pancreatic Pseudocyst: Report of Two Cases with Review of Literature
    Sunder Goyal, Sudhir Sachar, Ram Kumar Verma, Snigdha Goyal
    Arch Clin Exp Surg. 2013; 2(4): 251-258
    » Abstract & References » doi: 10.5455/aces.20120524103614

  • A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects
    Huseyin Karagoz, Celalettin Sever, Yalcin Bayram, Cihan Sahin, Yalcin Kulahci, Ersin Ulkur
    Arch Clin Exp Surg. 2012; 1(4): 237-248
    » Abstract & References » doi: 10.5455/aces.20120218124923

  • Role of Ultrasonography (“Honeycomb Sign”) in Early Detection of Dengue Hemorrhagic Fever
    Sudhir Sachar, Sunder Goyal, Saurabh Sachar
    Arch Clin Exp Surg. 2013; 2(1): 38-42
    » Abstract & References » doi: 10.5455/aces.20120828025157

  • Most Cited Articles
  • Hirudotherapy /Leech therapy: Applications and Indications in Surgery
    Swaid Abdullah, Latief M. Dar, Adil Rashid, Anita Tewari
    Arch Clin Exp Surg. 2012; 1(3): 172-180
    » Abstract & References » doi: 10.5455/aces.20120402072447
    Cited : 8 times [Click to see citing articles]

  • Experimental Craniofacial Composite Tissue Allotransplantation (CCTA) Models in Rats
    Yalcin Kulahci, Yalcin Bayram, Huseyin Karagoz, Celalettin Sever, Cihan Sahin
    Arch Clin Exp Surg. 2012; 1(3): 181-187
    » Abstract & References » doi: 10.5455/aces.20120514010906
    Cited : 7 times [Click to see citing articles]

  • Thoracodorsal Artery Perforator Flap: Basic Surgical Determinants
    Celalettin Sever, Yalcin Bayram, Cihan Sahin
    Arch Clin Exp Surg. 2012; 1(4): 270-271
    » Abstract & References » doi: 10.5455/aces.20120506072849
    Cited : 6 times [Click to see citing articles]

  • Pre-expanded Supraclavicular Flap for Post-burn Neck Contractures
    Celalettin Sever, Cihan Sahin
    Arch Clin Exp Surg. 2012; 1(1): 61-62
    » Abstract & References » doi: 10.5455/aces.20120205090034
    Cited : 4 times [Click to see citing articles]

  • What is the Most Appropriate Animal Model for Experimental Diabetic Neuropathy Studies ?
    Huseyin Karagoz, Mustafa Tansel Kendirli
    Arch Clin Exp Surg. 2012; 1(3): 199-200
    » Abstract & References » doi: 10.5455/aces.20120514012617
    Cited : 3 times [Click to see citing articles]

  • Anesthetic Burns – A Burn Injury Due to A Combination of Local Anaesthetic and Heat Pack
    Stuart Robert Walker
    Arch Clin Exp Surg. 2012; 1(2): 127-128
    » Abstract & References » doi: 10.5455/aces.20120206110836
    Cited : 3 times [Click to see citing articles]

  • Day–Care Surgery for Pilonidal Sinus Using Sinotomy Technique and Fibrin Glue Injection
    Selim Sozen, Vedat Ozturk, Koray Das, Hasan Erdem, Suleyman Cetinkunar, Ilhan Bali
    Arch Clin Exp Surg. 2012; 1(3): 138-141
    » Abstract & References » doi: 10.5455/aces.20120625121721
    Cited : 3 times [Click to see citing articles]

  • A Review of the Prevention and Treatment of Hypertrophic Scars: Part II. Experimental Studies
    Huseyin Karagoz, Yalcin Bayram, Celalettin Sever, Cihan Sahin, Yalcin Kulahci, Ersin Ulkur
    Arch Clin Exp Surg. 2013; 2(1): 49-58
    » Abstract & References » doi: 10.5455/aces.20120218125115
    Cited : 3 times [Click to see citing articles]

  • Students’ View of Evidence-Based Medicine: A Survey in Switzerland
    Reto Kaderli, Larissa Burghardt, Carina Hansali, Adrian Businger
    Arch Clin Exp Surg. 2012; 1(1): 34-40
    » Abstract & References » doi: 10.5455/aces.20120217124737
    Cited : 3 times [Click to see citing articles]

  • Surgical Safety Checklists in Operative Medicine in Switzerland
    Reto Kaderli, Ramona Cecini Hertig, Urban Laffer, Adrian P. Businger
    Arch Clin Exp Surg. 2012; 1(3): 158-167
    » Abstract & References » doi: 10.5455/aces.20120410120119
    Cited : 3 times [Click to see citing articles]